Vacuum freeze-drying technology in the bio-engineering, pharmaceutical industry, food industry, materials science and deep processing of agricultural and sideline products have a wide range of applications.
Drugs freeze-dried, including Western medicine and Chinese medicine in two parts. Western medicine freeze drying in the country has been a certain development, many of the larger pharmaceutical companies have freeze-drying equipment. In the injection, the freeze-drying process used more, improve the quality of drugs and storage period, both doctors and patients have brought benefits. There are few varieties of freeze-dried drugs, high product prices, dry technology is not advanced. In traditional Chinese medicine, limited to ginseng, velvet, yam, Cordyceps sinensis and other small amount of Chinese medicine freeze-dried, a large number of proprietary Chinese medicine has not yet used freeze-drying process, with a large gap between foreign countries. Japan a few years ago to carry out the "Chinese medicine West", changed the traditional Chinese medicine brew method to solve the traditional Chinese medicine can not be made into the tradition of injection or tablet, but also solve the problem of traditional Chinese medicine treatment of acute illness, so China's traditional Chinese medicine freeze- And product research has great potential to be tapped.
In the field of biotechnology products, freeze-drying technology is mainly used for the production of drugs such as serum, plasma, vaccine, enzyme, antibiotics and hormones; biochemical examination of drugs, immunology and bacteriological examination of drugs; blood, bacteria, arteries, bones , Skin, cornea, nerve tissue and a variety of organs such as long-term preservation.
The status and development of equipment
Freeze-drying technology applications and equipment are inseparable, so far, the form of freeze-drying equipment is divided into two types of intermittent and continuous, the size of the equipment from less than one square meter to tens of square meters The
Intermittent freeze-drying equipment
Intermittent freeze-drying equipment for multi-species small batch production, especially in the field of food for seasonal strong food production. Stand-alone operation, if a device failure, will not affect the normal operation of other equipment. The intermittent freeze-drying equipment facilitates the control of the heating temperature and the degree of vacuum at different stages of drying the material. Equipment manufacturing and maintenance easy to carry out. However, due to loading, unloading, starting and other operations take more time, so the equipment utilization is low, the production efficiency is not high.
Continuous freeze-drying equipment
At home and abroad began to explore and use continuous vacuum freeze-drying equipment. Continuous equipment is characterized by a wide variety of products and a large amount of production, adequate production of raw materials, especially for the production of slurry and granular products. Continuous equipment is easy to achieve automation control, simplifying the manual operation and management, the main drawback is the high cost.
With the end of GMP certification, domestic excellent pharmaceutical freeze-drying equipment has entered a modern stage, full-featured, reliable, stable performance, can be achieved online cleaning (CIP) or steam sterilization (SIP), the technical indicators Can meet the biological products and pharmaceutical freeze-dried production needs. In contrast, the specifications of foreign freeze-drying equipment than domestic and domestic, supporting well-equipped, energy-efficient structure is more refined, continuous freeze-drying equipment production capacity. In order to ensure the quality and energy saving of the freeze-dried products, freeze-drying equipment, such as spray-freeze equipment, is often used in combination with freeze-drying equipment and other drying equipment.